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تاثیر گانودرما روی بیماری میتوکندریایی

Ganoderma lucidem

Ganoderma lucidem or Reishi is a natural fungal component found in South Asia; it has been used in traditional medicine and was recently reported to enhance mitochondrial function via a number of mechanisms. The plant extract demonstrated antioxidant activity in rodent models,32 decreasing lipid peroxidation, increasing the activity of TCA cycle dehydrogenase enzymes and elevating levels of Respiratory Complexes I and II in the brains of rats administered the compound.33,34 The extract is a cocktail of terpenes, polyphenols, vitamin C, E and β carotenes.34 A recent study has found that Reishi may increase levels of mitochondrial biogenesis via activation of peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α) in cellular models of Huntington’s disease.35

https://academic.oup.com/bmb/article/116/1/5/401122

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